FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer

FOXA1 expression correlates with the breast cancer luminal subtype and patient survival. RNA and protein analysis of a panel of breast cancer cell lines revealed that BRCA1 deficiency is associated with the downregulation of FOXA1 expression. Knockdown of BRCA1 resulted in the downregulation of FOXA...

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Detalles Bibliográficos
Autores principales: Gong, C, Fujino, K, Monteiro, L J, Gomes, A R, Drost, R, Davidson-Smith, H, Takeda, S, Khoo, U S, Jonkers, J, Sproul, D, Lam, E W-F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430311/
https://www.ncbi.nlm.nih.gov/pubmed/25531315
http://dx.doi.org/10.1038/onc.2014.421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430311/
https://www.ncbi.nlm.nih.gov/pubmed/25531315
http://dx.doi.org/10.1038/onc.2014.421

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