Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia

The initiation and maintenance of a malignant phenotype requires complex and synergistic interactions of multiple oncogenic signals. The Hedgehog (HH)/GLI pathway has been implicated in a variety of cancer entities and targeted pathway inhibition is of therapeutic relevance. Signal cross-talk with o...

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Detalles Bibliográficos
Autores principales: Kern, D, Regl, G, Hofbauer, S W, Altenhofer, P, Achatz, G, Dlugosz, A, Schnidar, H, Greil, R, Hartmann, T N, Aberger, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430320/
https://www.ncbi.nlm.nih.gov/pubmed/25639866
http://dx.doi.org/10.1038/onc.2014.450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430320/
https://www.ncbi.nlm.nih.gov/pubmed/25639866
http://dx.doi.org/10.1038/onc.2014.450

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