Population pharmacokinetics of intravenous and oral panobinostat in patients with hematologic and solid tumors

PURPOSE: The study aimed to characterize the population pharmacokinetics of panobinostat, a pan-deacetylase inhibitor that has demonstrated efficacy in combination with bortezomib and dexamethasone in patients with multiple myeloma. METHODS: A nonlinear mixed-effect model was used to fit plasma pano...

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Detalles Bibliográficos
Autores principales: Savelieva, Marina, Woo, Margaret M., Schran, Horst, Mu, Song, Nedelman, Jerry, Capdeville, Renaud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Clinical Trial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430599/
https://www.ncbi.nlm.nih.gov/pubmed/25939707
http://dx.doi.org/10.1007/s00228-015-1846-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430599/
https://www.ncbi.nlm.nih.gov/pubmed/25939707
http://dx.doi.org/10.1007/s00228-015-1846-7

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