An internally and externally validated nomogram for predicting the risk of irinotecan-induced severe neutropenia in advanced colorectal cancer patients

BACKGROUND: In Asians, the risk of irinotecan-induced severe toxicities is related in part to UGT1A1*6 (UGT, UDP glucuronosyltransferase) and UGT1A1*28, variant alleles that reduce the elimination of SN-38, the active metabolite of irinotecan. We prospectively studied the relation between the UGT1A1...

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Detalles Bibliográficos
Autores principales: Ichikawa, W, Uehara, K, Minamimura, K, Tanaka, C, Takii, Y, Miyauchi, H, Sadahiro, S, Fujita, K, Moriwaki, T, Nakamura, M, Takahashi, T, Tsuji, A, Shinozaki, K, Morita, S, Ando, Y, Okutani, Y, Sugihara, M, Sugiyama, T, Ohashi, Y, Sakata, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Full Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430714/
https://www.ncbi.nlm.nih.gov/pubmed/25880011
http://dx.doi.org/10.1038/bjc.2015.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430714/
https://www.ncbi.nlm.nih.gov/pubmed/25880011
http://dx.doi.org/10.1038/bjc.2015.122

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