Marine lipopeptide Iturin A inhibits Akt mediated GSK3β and FoxO3a signaling and triggers apoptosis in breast cancer

Akt kinase is a critical component of the PI3K/Akt signaling pathway, which is frequently over expressed in human cancers including breast. Therapeutic regimens for inhibiting breast cancer with aberrant Akt activity are essential. Here, we evaluated antitumor effect of a marine bacteria derived lip...

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Detalles Bibliográficos
Autores principales: Dey, Goutam, Bharti, Rashmi, Dhanarajan, Gunaseelan, Das, Subhasis, Dey, Kaushik Kumar, Kumar, B N Prashanth, Sen, Ramkrishna, Mandal, Mahitosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431395/
https://www.ncbi.nlm.nih.gov/pubmed/25974307
http://dx.doi.org/10.1038/srep10316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431395/
https://www.ncbi.nlm.nih.gov/pubmed/25974307
http://dx.doi.org/10.1038/srep10316

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