Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer

Cancer stem cells (CSCs) are responsible for aggressive tumor growth, metastasis and therapy resistance. In this study, we evaluated the effects of Shikonin (Shk) on breast cancer and found its anti-CSC potential. Shk treatment decreased the expression of various epithelial to mesenchymal transition...

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Detalles Bibliográficos
Autores principales: Thakur, Ravi, Trivedi, Rachana, Rastogi, Namrata, Singh, Manisha, Mishra, Durga Prasad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431480/
https://www.ncbi.nlm.nih.gov/pubmed/25973915
http://dx.doi.org/10.1038/srep10194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431480/
https://www.ncbi.nlm.nih.gov/pubmed/25973915
http://dx.doi.org/10.1038/srep10194

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