Reduction-responsive cross-linked stearyl peptide for effective delivery of plasmid DNA

Low efficiency and significant toxicity are the main obstacles to successful gene delivery. We have developed a cationic reduction-responsive vector based on a disulfide cross-linked stearylated polyarginine peptide modified with histidine (C-SHR) for DNA delivery. The structure of the C-SHR was cha...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Chong, Tai, Zongguang, Wang, Xiaoyu, Liu, Jiyong, Zhu, Quangang, Wu, Xin, Zhang, Lijuan, Zhang, Wei, Tian, Jing, Gao, Yuan, Gao, Shen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431505/
https://www.ncbi.nlm.nih.gov/pubmed/26056440
http://dx.doi.org/10.2147/IJN.S82413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431505/
https://www.ncbi.nlm.nih.gov/pubmed/26056440
http://dx.doi.org/10.2147/IJN.S82413

Ejemplares similares