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Reduction-responsive cross-linked stearyl peptide for effective delivery of plasmid DNA

Low efficiency and significant toxicity are the main obstacles to successful gene delivery. We have developed a cationic reduction-responsive vector based on a disulfide cross-linked stearylated polyarginine peptide modified with histidine (C-SHR) for DNA delivery. The structure of the C-SHR was cha...

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Detalles Bibliográficos
Autores principales:	Yao, Chong, Tai, Zongguang, Wang, Xiaoyu, Liu, Jiyong, Zhu, Quangang, Wu, Xin, Zhang, Lijuan, Zhang, Wei, Tian, Jing, Gao, Yuan, Gao, Shen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431505/ https://www.ncbi.nlm.nih.gov/pubmed/26056440 http://dx.doi.org/10.2147/IJN.S82413

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