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Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites
The activities of many DNA-repair proteins are controlled through reversible covalent modification by ubiquitin and ubiquitin-like molecules. Nonhomologous end-joining (NHEJ) is the predominant DNA double-strand break (DSB) repair pathway in mammalian cells and is initiated by DSB ends being recogni...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431666/ https://www.ncbi.nlm.nih.gov/pubmed/25921528 http://dx.doi.org/10.1016/j.celrep.2015.03.058 |