APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

Accumulation of Aβ peptide fragments of the APP protein and neurofibrillary tangles of the microtubule-associated protein tau are the cellular hallmarks of Alzheimer’s disease (AD). To investigate the relationship between APP metabolism and tau protein levels and phosphorylation, we studied human-st...

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Detalles Bibliográficos
Autores principales: Moore, Steven, Evans, Lewis D.B., Andersson, Therese, Portelius, Erik, Smith, James, Dias, Tatyana B., Saurat, Nathalie, McGlade, Amelia, Kirwan, Peter, Blennow, Kaj, Hardy, John, Zetterberg, Henrik, Livesey, Frederick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431668/
https://www.ncbi.nlm.nih.gov/pubmed/25921538
http://dx.doi.org/10.1016/j.celrep.2015.03.068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431668/
https://www.ncbi.nlm.nih.gov/pubmed/25921538
http://dx.doi.org/10.1016/j.celrep.2015.03.068

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