Deletion of Protein Tyrosine Phosphatase 1B (PTP1B) Enhances Endothelial Cyclooxygenase 2 Expression and Protects Mice from Type 1 Diabetes-Induced Endothelial Dysfunction

Protein tyrosine phosphatase 1B (PTP1B) dephosphorylates receptors tyrosine kinase and acts as a molecular brake on insulin signaling pathway. Conditions of metabolic dysfunction increase PTP1B, when deletion of PTP1B protects against metabolic disorders by increasing insulin signaling. Although vas...

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Detalles Bibliográficos
Autores principales: Herre, David J., Norman, J. Blake, Anderson, Ruchi, Tremblay, Michel L., Huby, Anne-Cecile, Belin de Chantemèle, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431674/
https://www.ncbi.nlm.nih.gov/pubmed/25974252
http://dx.doi.org/10.1371/journal.pone.0126866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431674/
https://www.ncbi.nlm.nih.gov/pubmed/25974252
http://dx.doi.org/10.1371/journal.pone.0126866

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