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Deletion of Protein Tyrosine Phosphatase 1B (PTP1B) Enhances Endothelial Cyclooxygenase 2 Expression and Protects Mice from Type 1 Diabetes-Induced Endothelial Dysfunction

Protein tyrosine phosphatase 1B (PTP1B) dephosphorylates receptors tyrosine kinase and acts as a molecular brake on insulin signaling pathway. Conditions of metabolic dysfunction increase PTP1B, when deletion of PTP1B protects against metabolic disorders by increasing insulin signaling. Although vas...

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Detalles Bibliográficos
Autores principales:	Herre, David J., Norman, J. Blake, Anderson, Ruchi, Tremblay, Michel L., Huby, Anne-Cecile, Belin de Chantemèle, Eric J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431674/ https://www.ncbi.nlm.nih.gov/pubmed/25974252 http://dx.doi.org/10.1371/journal.pone.0126866

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