The impact of composite AUC estimates on the prediction of systemic exposure in toxicology experiments

Current toxicity protocols relate measures of systemic exposure (i.e. AUC, C(max)) as obtained by non-compartmental analysis to observed toxicity. A complicating factor in this practice is the potential bias in the estimates defining safe drug exposure. Moreover, it prevents the assessment of variab...

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Detalles Bibliográficos
Autores principales: Sahota, Tarjinder, Danhof, Meindert, Della Pasqua, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432106/
https://www.ncbi.nlm.nih.gov/pubmed/25868863
http://dx.doi.org/10.1007/s10928-015-9413-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432106/
https://www.ncbi.nlm.nih.gov/pubmed/25868863
http://dx.doi.org/10.1007/s10928-015-9413-5

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