Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood

The first order conditional estimation (FOCE) method is still one of the parameter estimation workhorses for nonlinear mixed effects (NLME) modeling used in population pharmacokinetics and pharmacodynamics. However, because this method involves two nested levels of optimizations, with respect to the...

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Detalles Bibliográficos
Autores principales: Almquist, Joachim, Leander, Jacob, Jirstrand, Mats
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432110/
https://www.ncbi.nlm.nih.gov/pubmed/25801663
http://dx.doi.org/10.1007/s10928-015-9409-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432110/
https://www.ncbi.nlm.nih.gov/pubmed/25801663
http://dx.doi.org/10.1007/s10928-015-9409-1

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