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Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood
The first order conditional estimation (FOCE) method is still one of the parameter estimation workhorses for nonlinear mixed effects (NLME) modeling used in population pharmacokinetics and pharmacodynamics. However, because this method involves two nested levels of optimizations, with respect to the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432110/ https://www.ncbi.nlm.nih.gov/pubmed/25801663 http://dx.doi.org/10.1007/s10928-015-9409-1 |