Tight regulation of the unfolded protein sensor Ire1 by its intramolecularly antagonizing subdomain

Accumulation of unfolded proteins in the endoplasmic reticulum (ER) accompanies ER stress and causes the type-I transmembrane protein Ire1 (also known as ERN1) to trigger the unfolded protein response (UPR). When dimerized, the core stress-sensing region (CSSR) of Ire1 directly captures unfolded pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Mathuranyanon, Rubwad, Tsukamoto, Tomoko, Takeuchi, Asumi, Ishiwata-Kimata, Yuki, Tsuchiya, Yuichi, Kohno, Kenji, Kimata, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432228/
https://www.ncbi.nlm.nih.gov/pubmed/25770101
http://dx.doi.org/10.1242/jcs.164111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432228/
https://www.ncbi.nlm.nih.gov/pubmed/25770101
http://dx.doi.org/10.1242/jcs.164111

Ejemplares similares