Cargando…

Tight regulation of the unfolded protein sensor Ire1 by its intramolecularly antagonizing subdomain

Accumulation of unfolded proteins in the endoplasmic reticulum (ER) accompanies ER stress and causes the type-I transmembrane protein Ire1 (also known as ERN1) to trigger the unfolded protein response (UPR). When dimerized, the core stress-sensing region (CSSR) of Ire1 directly captures unfolded pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mathuranyanon, Rubwad, Tsukamoto, Tomoko, Takeuchi, Asumi, Ishiwata-Kimata, Yuki, Tsuchiya, Yuichi, Kohno, Kenji, Kimata, Yukio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432228/ https://www.ncbi.nlm.nih.gov/pubmed/25770101 http://dx.doi.org/10.1242/jcs.164111

Ejemplares similares

Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
por: Promlek, Thanyarat, et al.
Publicado: (2011)

Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins
por: Kimata, Yukio, et al.
Publicado: (2007)

A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1
por: Kimata, Yukio, et al.
Publicado: (2004)

Fundamental and Applicative Aspects of the Unfolded Protein Response in Yeasts
por: Ishiwata-Kimata, Yuki, et al.
Publicado: (2023)

Induction of the Unfolded Protein Response at High Temperature in Saccharomyces cerevisiae
por: Hata, Tatsuya, et al.
Publicado: (2022)

The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress
por: Le, Quynh Giang, et al.
Publicado: (2021)

The unfolded protein response alongside the diauxic shift of yeast cells and its involvement in mitochondria enlargement
por: Tran, Duc Minh, et al.
Publicado: (2019)

Induction and Aggravation of the Endoplasmic-Reticulum Stress by Membrane-Lipid Metabolic Intermediate Phosphatidyl-N-Monomethylethanolamine
por: Ishiwata-Kimata, Yuki, et al.
Publicado: (2022)

Endoplasmic stress sensor Ire1 is involved in cytosolic/nuclear protein quality control in Pichia pastoris cells independent of HAC1
por: Fauzee, Yasmin Nabilah Binti Mohd, et al.
Publicado: (2023)

Aeration mitigates endoplasmic reticulum stress in Saccharomyces cerevisiae even without mitochondrial respiration
por: Phuong, Huong Thi, et al.
Publicado: (2021)

Acetic Acid Causes Endoplasmic Reticulum Stress and Induces the Unfolded Protein Response in Saccharomyces cerevisiae
por: Kawazoe, Nozomi, et al.
Publicado: (2017)

Myosin V attachment to cargo requires the tight association of two functional subdomains
por: Pashkova, Natasha, et al.
Publicado: (2005)

Positioning of subdomain IIId and apical loop of domain II of the hepatitis C IRES on the human 40S ribosome
por: Babaylova, Elena, et al.
Publicado: (2009)

IRE1-Independent Gain Control of the Unfolded Protein Response
por: Leber, Jess H, et al.
Publicado: (2004)

Cytomegalovirus Downregulates IRE1 to Repress the Unfolded Protein Response
por: Stahl, Sebastian, et al.
Publicado: (2013)

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
por: Ali, Maruf M U, et al.
Publicado: (2011)

An unfolded protein-induced conformational switch activates mammalian IRE1
por: Karagöz, G Elif, et al.
Publicado: (2017)

IRE1–XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells
por: Tsuchiya, Yuichi, et al.
Publicado: (2018)

Correction: IRE1–XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells
por: Tsuchiya, Yuichi, et al.
Publicado: (2019)

Functional analysis of the mammalian RNA ligase for IRE1 in the unfolded protein response
por: Poothong, Juthakorn, et al.
Publicado: (2017)

Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β
por: Oikawa, Daisuke, et al.
Publicado: (2012)

Unfolded protein-independent IRE1 activation contributes to multifaceted developmental processes in Arabidopsis
por: Mishiba, Kei-ichiro, et al.
Publicado: (2019)

The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions
por: Ma, Jacey H., et al.
Publicado: (2016)

Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response
por: Jiang, Dadi, et al.
Publicado: (2016)

The Sec61 translocon limits IRE1α signaling during the unfolded protein response
por: Sundaram, Arunkumar, et al.
Publicado: (2017)

Understanding the Role of the Unfolded Protein Response Sensor IRE1 in the Biology of Antigen Presenting Cells
por: Flores-Santibáñez, Felipe, et al.
Publicado: (2019)

On domain decomposition and subdomain iteration
por: Bjørhus, M
Publicado: (1995)

Unfolded protein response mediator, the IRE1α-XBP1 pathway is involved in osteoblast differentiation
por: Tohmonda, Takahide, et al.
Publicado: (2012)

Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1
por: Adams, Christopher J., et al.
Publicado: (2019)

The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1
por: Acosta-Alvear, Diego, et al.
Publicado: (2018)

Mouse Hepatitis Virus Infection Activates the IRE1/XBP1 Pathway of the Unfolded Protein Response
por: Bechill, John, et al.
Publicado: (2006)

Enteroviruses Manipulate the Unfolded Protein Response through Multifaceted Deregulation of the Ire1-Xbp1 Pathway
por: Shishova, Anna, et al.
Publicado: (2022)

The unfolded protein response components IRE1α and XBP1 promote human coronavirus infection
por: Oda, Jessica M., et al.
Publicado: (2023)

Intramolecular Cohesion of Coils Mediated by Phenylalanine–Glycine Motifs in the Natively Unfolded Domain of a Nucleoporin
por: Krishnan, V. V., et al.
Publicado: (2008)

Yip1A, a Novel Host Factor for the Activation of the IRE1 Pathway of the Unfolded Protein Response during Brucella Infection
por: Taguchi, Yuki, et al.
Publicado: (2015)

Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish
por: Ishikawa, Tokiro, et al.
Publicado: (2017)

Stepping toward a Macaque Model of HIV-1 Induced AIDS
por: Kimata, Jason T.
Publicado: (2014)

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains
por: Fiorini, Francesca, et al.
Publicado: (2013)

Novel prosurvival function of Yip1A in human cervical cancer cells: constitutive activation of the IRE1 and PERK pathways of the unfolded protein response
por: Taguchi, Yuki, et al.
Publicado: (2017)

The interplay of GTP-binding protein AGB1 with ER stress sensors IRE1a and IRE1b modulates Arabidopsis unfolded protein response and bacterial immunity
por: Afrin, Taiaba, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jm15g1oeafieeisvovc3hpcp72