Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy

Cyclic nucleotide-gated (CNG) channels are activated by binding of cyclic nucleotides. Although structural studies have identified the channel pore and selectivity filter, conformation changes associated with gating remain poorly understood. Here we combine single-molecule force spectroscopy (SMFS)...

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Detalles Bibliográficos
Autores principales: Maity, Sourav, Mazzolini, Monica, Arcangeletti, Manuel, Valbuena, Alejandro, Fabris, Paolo, Lazzarino, Marco, Torre, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432583/
https://www.ncbi.nlm.nih.gov/pubmed/25963832
http://dx.doi.org/10.1038/ncomms8093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432583/
https://www.ncbi.nlm.nih.gov/pubmed/25963832
http://dx.doi.org/10.1038/ncomms8093

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