The structure of FMNL2–Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation

Formins are actin polymerization factors that elongate unbranched actin filaments at the barbed end. Rho family GTPases activate Diaphanous-related formins through the relief of an autoregulatory interaction. The crystal structures of the N-terminal domains of human FMNL1 and FMNL2 in complex with a...

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Detalles Bibliográficos
Autores principales: Kühn, Sonja, Erdmann, Constanze, Kage, Frieda, Block, Jennifer, Schwenkmezger, Lisa, Steffen, Anika, Rottner, Klemens, Geyer, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432619/
https://www.ncbi.nlm.nih.gov/pubmed/25963737
http://dx.doi.org/10.1038/ncomms8088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432619/
https://www.ncbi.nlm.nih.gov/pubmed/25963737
http://dx.doi.org/10.1038/ncomms8088

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