Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation

DNMT1 is an important epigenetic regulator that plays a key role in the maintenance of DNA methylation. Here we determined the crystal structure of DNMT1 in complex with USP7 at 2.9 Å resolution. The interaction between the two proteins is primarily mediated by an acidic pocket in USP7 and Lysine re...

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Detalles Bibliográficos
Autores principales: Cheng, Jingdong, Yang, Huirong, Fang, Jian, Ma, Lixiang, Gong, Rui, Wang, Ping, Li, Ze, Xu, Yanhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432644/
https://www.ncbi.nlm.nih.gov/pubmed/25960197
http://dx.doi.org/10.1038/ncomms8023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432644/
https://www.ncbi.nlm.nih.gov/pubmed/25960197
http://dx.doi.org/10.1038/ncomms8023

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