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JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis

Histone 3 lysine 9 (H3K9) demethylase JMJD1A regulates β-adrenergic-induced systemic metabolism and body weight control. Here we show that JMJD1A is phosphorylated at S265 by protein kinase A (PKA), and this is pivotal to activate the β1-adrenergic receptor gene (Adrb1) and downstream targets includ...

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Detalles Bibliográficos
Autores principales: Abe, Yohei, Rozqie, Royhan, Matsumura, Yoshihiro, Kawamura, Takeshi, Nakaki, Ryo, Tsurutani, Yuya, Tanimura-Inagaki, Kyoko, Shiono, Akira, Magoori, Kenta, Nakamura, Kanako, Ogi, Shotaro, Kajimura, Shingo, Kimura, Hiroshi, Tanaka, Toshiya, Fukami, Kiyoko, Osborne, Timothy F., Kodama, Tatsuhiko, Aburatani, Hiroyuki, Inagaki, Takeshi, Sakai, Juro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432656/
https://www.ncbi.nlm.nih.gov/pubmed/25948511
http://dx.doi.org/10.1038/ncomms8052