The Processed Amino-Terminal Fragment of Human TLR7 Acts as a Chaperone To Direct Human TLR7 into Endosomes

TLR7 mediates innate immune responses to viral RNA in endocytic compartments. Mouse and human (h)TLR7 undergo proteolytic cleavage, resulting in the generation of a C-terminal fragment that accumulates in endosomes and associates with the signaling adaptor MyD88 upon receptor triggering by TLR7 agon...

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Detalles Bibliográficos
Autores principales: Hipp, Madeleine M., Shepherd, Dawn, Booth, Sarah, Waithe, Dominic, Reis e Sousa, Caetano, Cerundolo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2015
Materias:
Innate Immunity and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432728/
https://www.ncbi.nlm.nih.gov/pubmed/25917086
http://dx.doi.org/10.4049/jimmunol.1402703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432728/
https://www.ncbi.nlm.nih.gov/pubmed/25917086
http://dx.doi.org/10.4049/jimmunol.1402703

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