Cargando…

Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer’s disease: a voxel-based lesion mapping study

INTRODUCTION: White matter (WM) magnetic resonance imaging (MRI) hyperintensities are common in Alzheimer’s disease (AD), but their pathophysiological relevance and relationship to genetic factors are unclear. In the present study, we investigated potential apolipoprotein E (APOE)-dependent effects...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morgen, Katrin, Schneider, Michael, Frölich, Lutz, Tost, Heike, Plichta, Michael M, Kölsch, Heike, Rakebrandt, Fabian, Rienhoff, Otto, Jessen, Frank, Peters, Oliver, Jahn, Holger, Luckhaus, Christian, Hüll, Michael, Gertz, Hermann-Josef, Schröder, Johannes, Hampel, Harald, Teipel, Stefan J, Pantel, Johannes, Heuser, Isabella, Wiltfang, Jens, Rüther, Eckart, Kornhuber, Johannes, Maier, Wolfgang, Meyer-Lindenberg, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432954/ https://www.ncbi.nlm.nih.gov/pubmed/25984242 http://dx.doi.org/10.1186/s13195-015-0111-8

Ejemplares similares

Memory Concerns, Memory Performance and Risk of Dementia in Patients with Mild Cognitive Impairment
por: Wolfsgruber, Steffen, et al.
Publicado: (2014)

Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia
por: Frölich, Lutz, et al.
Publicado: (2017)

Combined treatment with memantine and galantamine-CR compared with galantamine-CR only in antidementia drug naïve patients with mild-to-moderate Alzheimer's disease
por: Peters, Oliver, et al.
Publicado: (2015)

A Comparison of Operational Definitions for Mild Cognitive Impairment
por: Polcher, Alexandra, et al.
Publicado: (2022)

Don’t forget about tau: the effects of ApoE4 genotype on Alzheimer’s disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment—data from the Dementia Competence Network
por: Benson, Gloria S., et al.
Publicado: (2022)

Identification of a Cascade of Changes in Activities of Daily Living Preceding Short-Term Clinical Deterioration in Mild Alzheimer’s Disease Dementia via Lead-Lag Analysis
por: Fuentes, Manuel, et al.
Publicado: (2020)

A statistical approach for segregating cognitive task stages from multivariate fMRI BOLD time series
por: Demanuele, Charmaine, et al.
Publicado: (2015)

CSF amyloid-β-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia
por: Bibl, Mirko, et al.
Publicado: (2006)

Optimal management of Alzheimer’s disease patients: Clinical guidelines and family advice
por: Haberstroh, Julia, et al.
Publicado: (2010)

Distributions of Aβ42 and Aβ42/40 in the Cerebrospinal Fluid in View of the Probability Theory
por: Lewczuk, Piotr, et al.
Publicado: (2021)

Transdiagnostic Prediction of Affective, Cognitive, and Social Function Through Brain Reward Anticipation in Schizophrenia, Bipolar Disorder, Major Depression, and Autism Spectrum Diagnoses
por: Schwarz, Kristina, et al.
Publicado: (2020)

Finite-element-method (FEM) model generation of time-resolved 3D echocardiographic geometry data for mitral-valve volumetry
por: Verhey, Janko F, et al.
Publicado: (2006)

Advancing translational research in neuroscience through multi-task learning
por: Cao, Han, et al.
Publicado: (2022)

Biological markers for early detection and pharmacological treatment of Alzheimer's disease
por: Hampel, Harald, et al.
Publicado: (2009)

Key components and IT assistance of participant management in clinical research: a scoping review
por: Pung, Johannes, et al.
Publicado: (2020)

Sektorenübergreifende Therapiekonzepte und innovative Technologien: neue Möglichkeiten für die Versorgung von Patienten mit psychischen Erkrankungen
por: Hirjak, Dusan, et al.
Publicado: (2021)

Directed coupling in multi-brain networks underlies generalized synchrony during social exchange
por: Bilek, Edda, et al.
Publicado: (2022)

No association between cardiometabolic risk and neural reactivity to acute psychosocial stress
por: Lederbogen, Florian, et al.
Publicado: (2018)

Cortical tau load is associated with white matter hyperintensities
por: McAleese, Kirsty E., et al.
Publicado: (2015)

Hyperintense Acute Reperfusion Marker on FLAIR in Posterior Circulation Infarction
por: Förster, Alex, et al.
Publicado: (2016)

Neural responses to social evaluative threat in the absence of negative investigator feedback and provoked performance failures
por: Fehlner, Phöbe, et al.
Publicado: (2020)

Identification of Reproducible BCL11A Alterations in Schizophrenia Through Individual-Level Prediction of Coexpression
por: Chen, Junfang, et al.
Publicado: (2020)

Bupropion for the Treatment of Apathy in Alzheimer Disease: A Randomized Clinical Trial
por: Maier, Franziska, et al.
Publicado: (2020)

RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism
por: Kölsch, Heike, et al.
Publicado: (2009)

Performance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia
por: Gaubert, Malo, et al.
Publicado: (2023)

Cerebrospinal fluid amyloid-β 2-42 is decreased in Alzheimer’s, but not in frontotemporal dementia
por: Bibl, Mirko, et al.
Publicado: (2012)

Combined Analysis of CSF Tau, Aβ42, Aβ1–42% and Aβ1–40(ox)% in Alzheimer's Disease, Dementia with Lewy Bodies and Parkinson's Disease Dementia
por: Bibl, Mirko, et al.
Publicado: (2010)

White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly
por: Becktepe, Jos S., et al.
Publicado: (2021)

Within-Subject Associations between Mood Dimensions and Non-exercise Activity: An Ambulatory Assessment Approach Using Repeated Real-Time and Objective Data
por: Reichert, Markus, et al.
Publicado: (2016)

Patients with affective disorders profit most from telemedical treatment: Evidence from a naturalistic patient cohort during the COVID-19 pandemic
por: Rohrmann, Tobias, et al.
Publicado: (2022)

Female sex and burden of depressive symptoms predict insufficient response to telemedical treatment in adult attention-deficit/hyperactivity disorder: results from a naturalistic patient cohort during the COVID-19 pandemic
por: Praus, Peter, et al.
Publicado: (2023)

VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation
por: Marinova, Milka, et al.
Publicado: (2012)

A multiphysics model to predict periventricular white matter hyperintensity growth during healthy brain aging
por: Caçoilo, Andreia, et al.
Publicado: (2023)

The Effect of Training Sample Size on the Prediction of White Matter Hyperintensity Volume in a Healthy Population Using BIANCA
por: Wulms, Niklas, et al.
Publicado: (2022)

Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes
por: Spitzer, Philipp, et al.
Publicado: (2010)

Gesundheitliche Risiken von Einsamkeit und sozialer Isolation im Alter
por: Pantel, Johannes
Publicado: (2021)

3D finite-element brain modeling of lateral ventricular wall loading to rationalize periventricular white matter hyperintensity locations
por: Caçoilo, Andreia, et al.
Publicado: (2022)

The Role of Cathepsin B in the Degradation of Aβ and in the Production of Aβ Peptides Starting With Ala2 in Cultured Astrocytes
por: Oberstein, Timo Jan, et al.
Publicado: (2021)

Validation of Automated White Matter Hyperintensity Segmentation
por: Smart, Sean D., et al.
Publicado: (2011)

Anticonvulsants in the treatment of aggression in the demented elderly: an update
por: Amann, Benedikt, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_j2s2bd0hadkov18df7gn66k4d3