Cargando…
Premature Expression of Foxp3 in Double-Negative Thymocytes
Peripheral immune regulation depends on the generation of thymic-derived regulatory T (tT(reg)) cells to maintain self-tolerance and to counterbalance overshooting immune responses. The expression of the T(reg) lineage defining transcription factor Foxp3 in developing tT(reg) cells depends on TCR si...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433242/ https://www.ncbi.nlm.nih.gov/pubmed/25978037 http://dx.doi.org/10.1371/journal.pone.0127038 |