Stress-induced inhibition of nonsense mediated RNA decay regulates intracellular cystine transport and intracellular glutathione through regulation of the cystine/glutamate exchanger SLC7A11

SLC7A11 encodes a subunit of the xCT cystine/glutamate amino acid transport system and plays a critical role in the generation of glutathione and the protection of cells from oxidative stress. Expression of SLC7A11 promotes tumorigenesis and chemotherapy resistance, but while SLC7A11 has been previo...

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Detalles Bibliográficos
Autores principales: Martin, Leenus, Gardner, Lawrence B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433865/
https://www.ncbi.nlm.nih.gov/pubmed/25399695
http://dx.doi.org/10.1038/onc.2014.352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433865/
https://www.ncbi.nlm.nih.gov/pubmed/25399695
http://dx.doi.org/10.1038/onc.2014.352

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