Role of endothelin-1 antagonist; bosentan, against cisplatin-induced nephrotoxicity in male and female rats

BACKGROUND: Cisplatin (CP) is a chemotherapy drug, with the major side effect of nephrotoxicity. The level of endothelin-1 (ET-1) increases during nephrotoxicity, which is accompanied with vasoconstrictive properties. Bosentan (BOS) is a nonselective ET-1 receptor antagonist, having vasodilatory and...

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Detalles Bibliográficos
Autores principales: Jokar, Zahra, Nematbakhsh, Mehdi, Moeini, Maryam, Talebi, Ardeshir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434484/
https://www.ncbi.nlm.nih.gov/pubmed/26015909
http://dx.doi.org/10.4103/2277-9175.156642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434484/
https://www.ncbi.nlm.nih.gov/pubmed/26015909
http://dx.doi.org/10.4103/2277-9175.156642

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