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Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast

Antitumor substances related to vinblastine and vincristine are exclusively found in the Catharanthus roseus (Madagascar periwinkle), a member of the Apocynaceae plant family, and continue to be extensively used in cancer chemotherapy. Although in high demand, these valuable compounds only accumulat...

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Detalles Bibliográficos
Autores principales: Qu, Yang, Easson, Michael L. A. E., Froese, Jordan, Simionescu, Razvan, Hudlicky, Tomas, De Luca, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434687/
https://www.ncbi.nlm.nih.gov/pubmed/25918424
http://dx.doi.org/10.1073/pnas.1501821112