The cytosolic tail of the tumor marker protein Trop2 - a structural switch triggered by phosphorylation

Trop2 is a transmembrane signaling glycoprotein upregulated in stem and carcinoma cells. Proliferation-enhancing signaling involves regulated intramembrane proteolytic release of a short cytoplasmic fragment, which is later engaged in a cytosolic signaling complex. We propose that Trop2 function is...

Descripción completa

Detalles Bibliográficos
Autores principales: Pavšič, Miha, Ilc, Gregor, Vidmar, Tilen, Plavec, Janez, Lenarčič, Brigita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434849/
https://www.ncbi.nlm.nih.gov/pubmed/25981199
http://dx.doi.org/10.1038/srep10324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434849/
https://www.ncbi.nlm.nih.gov/pubmed/25981199
http://dx.doi.org/10.1038/srep10324

Ejemplares similares