Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein

Accumulating evidence suggests that deposition of neurotoxic α-synuclein aggregates in the brain during the development of neurodegenerative diseases like Parkinson’s disease can be curbed by anti-aggregation strategies that either disrupt or eliminate toxic aggregates. Curcumin, a dietary polypheno...

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Detalles Bibliográficos
Autores principales: Ahsan, Nuzhat, Mishra, Satyendra, Jain, Manish Kumar, Surolia, Avadhesha, Gupta, Sarika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435243/
https://www.ncbi.nlm.nih.gov/pubmed/25985292
http://dx.doi.org/10.1038/srep09862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435243/
https://www.ncbi.nlm.nih.gov/pubmed/25985292
http://dx.doi.org/10.1038/srep09862

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