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Inferring Broad Regulatory Biology from Time Course Data: Have We Reached an Upper Bound under Constraints Typical of In Vivo Studies?

There is a growing appreciation for the network biology that regulates the coordinated expression of molecular and cellular markers however questions persist regarding the identifiability of these networks. Here we explore some of the issues relevant to recovering directed regulatory networks from t...

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Detalles Bibliográficos
Autores principales: Vashishtha, Saurabh, Broderick, Gordon, Craddock, Travis J. A., Fletcher, Mary Ann, Klimas, Nancy G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435750/
https://www.ncbi.nlm.nih.gov/pubmed/25984725
http://dx.doi.org/10.1371/journal.pone.0127364