The prion protein regulates beta-amyloid-mediated self-renewal of neural stem cells in vitro

The beta-amyloid (Aβ) peptide and the Aβ-oligomer receptor, prion protein (PrP), both influence neurogenesis. Using in vitro murine neural stem cells (NSCs), we investigated whether Aβ and PrP interact to modify neurogenesis. Aβ imparted PrP-dependent changes on NSC self-renewal, with PrP-ablated an...

Descripción completa

Detalles Bibliográficos
Autores principales: Collins, Steven J, Tumpach, Carolin, Li, Qiao-Xin, Lewis, Victoria, Ryan, Timothy M, Roberts, Blaine, Drew, Simon C, Lawson, Victoria A, Haigh, Cathryn L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435829/
https://www.ncbi.nlm.nih.gov/pubmed/25884827
http://dx.doi.org/10.1186/s13287-015-0067-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435829/
https://www.ncbi.nlm.nih.gov/pubmed/25884827
http://dx.doi.org/10.1186/s13287-015-0067-4

Ejemplares similares