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Evidence for Posttranslational Protein Flavinylation in the Syphilis Spirochete Treponema pallidum: Structural and Biochemical Insights from the Catalytic Core of a Periplasmic Flavin-Trafficking Protein

The syphilis spirochete Treponema pallidum is an important human pathogen but a highly enigmatic bacterium that cannot be cultivated in vitro. T. pallidum lacks many biosynthetic pathways and therefore has evolved the capability to exploit host-derived metabolites via its periplasmic lipoprotein rep...

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Detalles Bibliográficos
Autores principales: Deka, Ranjit K., Brautigam, Chad A., Liu, Wei Z., Tomchick, Diana R., Norgard, Michael V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436053/
https://www.ncbi.nlm.nih.gov/pubmed/25944861
http://dx.doi.org/10.1128/mBio.00519-15