Partial protein domains: evolutionary insights and bioinformatics challenges

Protein domains are generally thought to correspond to units of evolution. New research raises questions about how such domains are defined with bioinformatics tools and sheds light on how evolution has enabled partial domains to be viable.

Detalles Bibliográficos
Autores principales: Kelley, Lawrence A, Sternberg, Michael JE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436111/
https://www.ncbi.nlm.nih.gov/pubmed/25986583
http://dx.doi.org/10.1186/s13059-015-0663-8
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author Kelley, Lawrence A
Sternberg, Michael JE
author_facet Kelley, Lawrence A
Sternberg, Michael JE
author_sort Kelley, Lawrence A
collection PubMed
description Protein domains are generally thought to correspond to units of evolution. New research raises questions about how such domains are defined with bioinformatics tools and sheds light on how evolution has enabled partial domains to be viable.
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spelling pubmed-44361112015-05-20 Partial protein domains: evolutionary insights and bioinformatics challenges Kelley, Lawrence A Sternberg, Michael JE Genome Biol Research Highlight Protein domains are generally thought to correspond to units of evolution. New research raises questions about how such domains are defined with bioinformatics tools and sheds light on how evolution has enabled partial domains to be viable. BioMed Central 2015-05-19 2015 /pmc/articles/PMC4436111/ /pubmed/25986583 http://dx.doi.org/10.1186/s13059-015-0663-8 Text en © Kelley and Sternberg; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise credited.
spellingShingle Research Highlight
Kelley, Lawrence A
Sternberg, Michael JE
Partial protein domains: evolutionary insights and bioinformatics challenges
title Partial protein domains: evolutionary insights and bioinformatics challenges
title_full Partial protein domains: evolutionary insights and bioinformatics challenges
title_fullStr Partial protein domains: evolutionary insights and bioinformatics challenges
title_full_unstemmed Partial protein domains: evolutionary insights and bioinformatics challenges
title_short Partial protein domains: evolutionary insights and bioinformatics challenges
title_sort partial protein domains: evolutionary insights and bioinformatics challenges
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436111/
https://www.ncbi.nlm.nih.gov/pubmed/25986583
http://dx.doi.org/10.1186/s13059-015-0663-8
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AT sternbergmichaelje partialproteindomainsevolutionaryinsightsandbioinformaticschallenges

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