Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats

BACKGROUND: Phospholipase A2 (PLA2)-derived proinflammatory lipid mediators such as prostaglandin E2 (PGE2), leukotrienes B4 (LTB4), lysophosphatidylcholine (LPC), and free fatty acids (FFA) are implicated in spinal cord injury (SCI) pathologies. Reducing the levels of these injurious bioactive lipi...

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Detalles Bibliográficos
Autores principales: Khan, Mushfiquddin, Shunmugavel, Anandakumar, Dhammu, Tajinder S, Matsuda, Fumiyo, Singh, Avtar K, Singh, Inderjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436116/
https://www.ncbi.nlm.nih.gov/pubmed/25971887
http://dx.doi.org/10.1186/s12974-015-0311-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436116/
https://www.ncbi.nlm.nih.gov/pubmed/25971887
http://dx.doi.org/10.1186/s12974-015-0311-y

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