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Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats
BACKGROUND: Phospholipase A2 (PLA2)-derived proinflammatory lipid mediators such as prostaglandin E2 (PGE2), leukotrienes B4 (LTB4), lysophosphatidylcholine (LPC), and free fatty acids (FFA) are implicated in spinal cord injury (SCI) pathologies. Reducing the levels of these injurious bioactive lipi...
Autores principales: | Khan, Mushfiquddin, Shunmugavel, Anandakumar, Dhammu, Tajinder S, Matsuda, Fumiyo, Singh, Avtar K, Singh, Inderjit |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436116/ https://www.ncbi.nlm.nih.gov/pubmed/25971887 http://dx.doi.org/10.1186/s12974-015-0311-y |
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