Functionalized self-assembling peptide improves INS-1 β-cell function and proliferation via the integrin/FAK/ERK/cyclin pathway

Islet transplantation is considered to be a curative treatment for type 1 diabetes mellitus. However, disruption of the extracellular matrix (ECM) leads to β-cell destruction and graft dysfunction. In this study, we developed a functionalized self-assembling peptide, KLD-F, with ECM mimic motifs der...

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Detalles Bibliográficos
Autores principales: Liu, Jingping, Liu, Shuyun, Chen, Younan, Zhao, Xiaojun, Lu, Yanrong, Cheng, Jingqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436204/
https://www.ncbi.nlm.nih.gov/pubmed/25999715
http://dx.doi.org/10.2147/IJN.S80502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436204/
https://www.ncbi.nlm.nih.gov/pubmed/25999715
http://dx.doi.org/10.2147/IJN.S80502

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