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Mutations associated with Dent's disease affect gating and voltage dependence of the human anion/proton exchanger ClC-5
Dent's disease is associated with impaired renal endocytosis and endosomal acidification. It is linked to mutations in the membrane chloride/proton exchanger ClC-5; however, a direct link between localization in the protein and functional phenotype of the mutants has not been established until...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436585/ https://www.ncbi.nlm.nih.gov/pubmed/26042048 http://dx.doi.org/10.3389/fphys.2015.00159 |