Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic

Two ER membrane-resident transmembrane kinases, IRE1 and PERK, function as stress sensors in the unfolded protein response. IRE1 also has an endoribonuclease activity, which initiates a non-conventional mRNA splicing reaction, while PERK phosphorylates eIF2α. We engineered a potent small molecule, I...

Descripción completa

Detalles Bibliográficos
Autores principales: Mendez, Aaron S, Alfaro, Jennifer, Morales-Soto, Marisol A, Dar, Arvin C, McCullagh, Emma, Gotthardt, Katja, Li, Han, Acosta-Alvear, Diego, Sidrauski, Carmela, Korennykh, Alexei V, Bernales, Sebastian, Shokat, Kevan M, Walter, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436593/
https://www.ncbi.nlm.nih.gov/pubmed/25986605
http://dx.doi.org/10.7554/eLife.05434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436593/
https://www.ncbi.nlm.nih.gov/pubmed/25986605
http://dx.doi.org/10.7554/eLife.05434

Ejemplares similares