Tumor-specific mutations in low-frequency genes affect their functional properties

Causal genetic changes in oligodendrogliomas (OD) with 1p/19q co-deletion include mutations in IDH1, IDH2, CIC, FUBP1, TERT promoter and NOTCH1. However, it is generally assumed that more somatic mutations are required for tumorigenesis. This study aimed to establish whether genes mutated at low fre...

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Detalles Bibliográficos
Autores principales: Erdem-Eraslan, Lale, Heijsman, Daphne, de Wit, Maurice, Kremer, Andreas, Sacchetti, Andrea, van der Spek, Peter J., Smitt, Peter A. E. Sillevis, French, Pim J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Laboratory Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436689/
https://www.ncbi.nlm.nih.gov/pubmed/25694352
http://dx.doi.org/10.1007/s11060-015-1741-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436689/
https://www.ncbi.nlm.nih.gov/pubmed/25694352
http://dx.doi.org/10.1007/s11060-015-1741-1

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