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A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import
Torsin proteins are AAA+ ATPases that localize to the endoplasmic reticular/nuclear envelope (ER/NE) lumen. A mutation that markedly impairs torsinA function causes the CNS disorder DYT1 dystonia. Abnormalities of NE membranes have been linked to torsinA loss of function and the pathogenesis of DYT1...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436785/ https://www.ncbi.nlm.nih.gov/pubmed/25739455 http://dx.doi.org/10.1091/mbc.E14-07-1239 |