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Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution

In preclinical and clinical studies aging has been associated with a deteriorated response to antidepressant treatment. We hypothesize that such impairment is explained by an age-related decrease in brain serotonin transporter (SERT) expression associated with low testosterone (T) levels. The object...

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Autores principales: Herrera-Pérez, José Jaime, Fernández-Guasti, Alonso, Martínez-Mota, Lucía
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437264/
https://www.ncbi.nlm.nih.gov/pubmed/26317087
http://dx.doi.org/10.1155/2013/201909
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author Herrera-Pérez, José Jaime
Fernández-Guasti, Alonso
Martínez-Mota, Lucía
author_facet Herrera-Pérez, José Jaime
Fernández-Guasti, Alonso
Martínez-Mota, Lucía
author_sort Herrera-Pérez, José Jaime
collection PubMed
description In preclinical and clinical studies aging has been associated with a deteriorated response to antidepressant treatment. We hypothesize that such impairment is explained by an age-related decrease in brain serotonin transporter (SERT) expression associated with low testosterone (T) levels. The objectives of this study were to establish (1) if brain SERT expression is reduced by aging and (2) if the SERT expression in middle-aged rats is increased by T-restitution. Intact young rats (3–5 months) and gonad-intact middle-aged rats with or without T-restitution were used. The identification of the brain SERT expression was done by immunofluorescence in prefrontal cortex, lateral septum, hippocampus, and raphe nuclei. An age-dependent reduction of SERT expression was observed in all brain regions examined, while T-restitution recovered the SERT expression only in the dorsal raphe of middle-aged rats. This last action seems relevant since dorsal raphe plays an important role in the antidepressant action of selective serotonin reuptake inhibitors. All data suggest that this mechanism accounts for the T-replacement usefulness to improve the response to antidepressants in the aged population.
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spelling pubmed-44372642015-08-27 Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution Herrera-Pérez, José Jaime Fernández-Guasti, Alonso Martínez-Mota, Lucía Neurosci J Research Article In preclinical and clinical studies aging has been associated with a deteriorated response to antidepressant treatment. We hypothesize that such impairment is explained by an age-related decrease in brain serotonin transporter (SERT) expression associated with low testosterone (T) levels. The objectives of this study were to establish (1) if brain SERT expression is reduced by aging and (2) if the SERT expression in middle-aged rats is increased by T-restitution. Intact young rats (3–5 months) and gonad-intact middle-aged rats with or without T-restitution were used. The identification of the brain SERT expression was done by immunofluorescence in prefrontal cortex, lateral septum, hippocampus, and raphe nuclei. An age-dependent reduction of SERT expression was observed in all brain regions examined, while T-restitution recovered the SERT expression only in the dorsal raphe of middle-aged rats. This last action seems relevant since dorsal raphe plays an important role in the antidepressant action of selective serotonin reuptake inhibitors. All data suggest that this mechanism accounts for the T-replacement usefulness to improve the response to antidepressants in the aged population. Hindawi Publishing Corporation 2013 2013-12-18 /pmc/articles/PMC4437264/ /pubmed/26317087 http://dx.doi.org/10.1155/2013/201909 Text en Copyright © 2013 José Jaime Herrera-Pérez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Herrera-Pérez, José Jaime
Fernández-Guasti, Alonso
Martínez-Mota, Lucía
Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution
title Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution
title_full Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution
title_fullStr Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution
title_full_unstemmed Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution
title_short Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution
title_sort brain sert expression of male rats is reduced by aging and increased by testosterone restitution
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437264/
https://www.ncbi.nlm.nih.gov/pubmed/26317087
http://dx.doi.org/10.1155/2013/201909
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