Triplex real-time PCR–an improved method to detect a wide spectrum of mitochondrial DNA deletions in single cells

Mitochondrial DNA (mtDNA) mutations are commonly found in the skeletal muscle of patients with mitochondrial disease, inflammatory myopathies and sarcopenia. The majority of these mutations are mtDNA deletions, which accumulate to high levels in individual muscle fibres causing a respiratory defect....

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Detalles Bibliográficos
Autores principales: Rygiel, Karolina A., Grady, John P., Taylor, Robert W., Tuppen, Helen A. L., Turnbull, Doug M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437295/
https://www.ncbi.nlm.nih.gov/pubmed/25989140
http://dx.doi.org/10.1038/srep09906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437295/
https://www.ncbi.nlm.nih.gov/pubmed/25989140
http://dx.doi.org/10.1038/srep09906

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