Increasing Membrane Cholesterol Level Increases the Amyloidogenic Peptide by Enhancing the Expression of Phospholipase C

Cerebral elevation of 42-residue amyloid β-peptide (Aβ42) triggers neuronal dysfunction in Alzheimer's disease (AD). Even though a number of cholesterol modulating agents have been shown to affect Aβ generation, the role of cholesterol in the pathogenesis of AD is not clear yet. Recently, we ha...

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Detalles Bibliográficos
Autores principales: Chun, Yoon Sun, Oh, Hyun Geun, Park, Myoung Kyu, Kim, Tae-Wan, Chung, Sungkwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437359/
https://www.ncbi.nlm.nih.gov/pubmed/26316988
http://dx.doi.org/10.1155/2013/407903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437359/
https://www.ncbi.nlm.nih.gov/pubmed/26316988
http://dx.doi.org/10.1155/2013/407903

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