Repositioning of Memantine as a Potential Novel Therapeutic Agent against Meningitic E. coli–Induced Pathogenicities through Disease-Associated Alpha7 Cholinergic Pathway and RNA Sequencing-Based Transcriptome Analysis of Host Inflammatory Responses

Neonatal sepsis and meningitis (NSM) remains a leading cause worldwide of mortality and morbidity in newborn infants despite the availability of antibiotics over the last several decades. E. coli is the most common gram-negative pathogen causing NSM. Our previous studies show that α7 nicotinic recep...

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Detalles Bibliográficos
Autores principales: Yu, Jing-Yi, Zhang, Bao, Peng, Liang, Wu, Chun-Hua, Cao, Hong, Zhong, John F., Hoffman, Jill, Huang, Sheng-He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437645/
https://www.ncbi.nlm.nih.gov/pubmed/25993608
http://dx.doi.org/10.1371/journal.pone.0121911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437645/
https://www.ncbi.nlm.nih.gov/pubmed/25993608
http://dx.doi.org/10.1371/journal.pone.0121911

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