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TRAFD1 (FLN29) Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption

Plekhm1 is a large, multi-modular, adapter protein implicated in osteoclast vesicle trafficking and bone resorption. In patients, inactivating mutations cause osteopetrosis, and gain-of-function mutations cause osteopenia. Investigations of potential Plekhm1 interaction partners by mass spectrometry...

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Detalles Bibliográficos
Autores principales: Witwicka, Hanna, Jia, Hong, Kutikov, Artem, Reyes-Gutierrez, Pablo, Li, Xiangdong, Odgren, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438057/
https://www.ncbi.nlm.nih.gov/pubmed/25992615
http://dx.doi.org/10.1371/journal.pone.0127537