Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site

Enzymes enable life by accelerating reaction rates to biological timescales. Conventional studies have focused on identifying the residues that have a direct involvement in an enzymatic reaction, but these so-called ‘catalytic residues’ are embedded in extensive interaction networks. Although fundam...

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Detalles Bibliográficos
Autores principales: Sunden, Fanny, Peck, Ariana, Salzman, Julia, Ressl, Susanne, Herschlag, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438272/
https://www.ncbi.nlm.nih.gov/pubmed/25902402
http://dx.doi.org/10.7554/eLife.06181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438272/
https://www.ncbi.nlm.nih.gov/pubmed/25902402
http://dx.doi.org/10.7554/eLife.06181

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