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Continuous de novo biosynthesis of haem and its rapid turnover to bilirubin are necessary for cytoprotection against cell damage

It is well known that haem serves as the prosthetic group of various haemoproteins that function in oxygen transport, respiratory chain, and drug metabolism. However, much less is known about the functions of the catabolites of haem in mammalian cells. Haem is enzymatically degraded to iron, carbon...

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Detalles Bibliográficos
Autores principales: Takeda, Taka-aki, Mu, Anfeng, Tai, Tran Tien, Kitajima, Sakihito, Taketani, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438432/
https://www.ncbi.nlm.nih.gov/pubmed/25990790
http://dx.doi.org/10.1038/srep10488