Amyloid β peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/HSP90 interaction and disruption of agonist-mediated Akt activation

BACKGROUND: Amyloid β (Aβ)-induced vascular dysfunction significantly contributes to the pathogenesis of Alzheimer’s disease (AD). Aβ is known to impair endothelial nitric oxide synthase (eNOS) activity, thus inhibiting endothelial nitric oxide production (NO). METHOD: In this study, we investigated...

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Detalles Bibliográficos
Autores principales: Lamoke, Folami, Mazzone, Valeria, Persichini, Tiziana, Maraschi, Annamaria, Harris, Michael Brennan, Venema, Richard C, Colasanti, Marco, Gliozzi, Micaela, Muscoli, Carolina, Bartoli, Manuela, Mollace, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438457/
https://www.ncbi.nlm.nih.gov/pubmed/25935150
http://dx.doi.org/10.1186/s12974-015-0304-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438457/
https://www.ncbi.nlm.nih.gov/pubmed/25935150
http://dx.doi.org/10.1186/s12974-015-0304-x

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