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Anti-CCL2: building a reservoir or opening the floodgates to metastasis?

Neutralisation of macrophage chemoattractant C-C chemokine ligand 2 (CCL2) has shown reduced metastasis and enhanced survival in numerous experimental models of tumorigenesis. However, important new findings reported in Nature by Momo Bentires-Alj’s laboratory demonstrate that withdrawal of anti-CCL...

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Detalles Bibliográficos
Autores principales: Hitchcock, Jessica R, Watson, Christine J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438584/
https://www.ncbi.nlm.nih.gov/pubmed/25990313
http://dx.doi.org/10.1186/s13058-015-0573-4
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author Hitchcock, Jessica R
Watson, Christine J
author_facet Hitchcock, Jessica R
Watson, Christine J
author_sort Hitchcock, Jessica R
collection PubMed
description Neutralisation of macrophage chemoattractant C-C chemokine ligand 2 (CCL2) has shown reduced metastasis and enhanced survival in numerous experimental models of tumorigenesis. However, important new findings reported in Nature by Momo Bentires-Alj’s laboratory demonstrate that withdrawal of anti-CCL2 treatment accelerates lung metastasis and death in mice. The study highlights the need to consider longer term consequences of therapeutic intervention of metastatic disease, especially with regard to transient interference with the tumour microenvironment.
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spelling pubmed-44385842015-05-21 Anti-CCL2: building a reservoir or opening the floodgates to metastasis? Hitchcock, Jessica R Watson, Christine J Breast Cancer Res Viewpoint Neutralisation of macrophage chemoattractant C-C chemokine ligand 2 (CCL2) has shown reduced metastasis and enhanced survival in numerous experimental models of tumorigenesis. However, important new findings reported in Nature by Momo Bentires-Alj’s laboratory demonstrate that withdrawal of anti-CCL2 treatment accelerates lung metastasis and death in mice. The study highlights the need to consider longer term consequences of therapeutic intervention of metastatic disease, especially with regard to transient interference with the tumour microenvironment. BioMed Central 2015-05-21 2015 /pmc/articles/PMC4438584/ /pubmed/25990313 http://dx.doi.org/10.1186/s13058-015-0573-4 Text en © Hitchcock and Watson; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Viewpoint
Hitchcock, Jessica R
Watson, Christine J
Anti-CCL2: building a reservoir or opening the floodgates to metastasis?
title Anti-CCL2: building a reservoir or opening the floodgates to metastasis?
title_full Anti-CCL2: building a reservoir or opening the floodgates to metastasis?
title_fullStr Anti-CCL2: building a reservoir or opening the floodgates to metastasis?
title_full_unstemmed Anti-CCL2: building a reservoir or opening the floodgates to metastasis?
title_short Anti-CCL2: building a reservoir or opening the floodgates to metastasis?
title_sort anti-ccl2: building a reservoir or opening the floodgates to metastasis?
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438584/
https://www.ncbi.nlm.nih.gov/pubmed/25990313
http://dx.doi.org/10.1186/s13058-015-0573-4
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