Quantitative High-Throughput Identification of Drugs as Modulators of Human Constitutive Androstane Receptor

The constitutive androstane receptor (CAR, NR1I3) plays a key role in governing the transcription of numerous hepatic genes that involve xenobiotic metabolism/clearance, energy homeostasis, and cell proliferation. Thus, identification of novel human CAR (hCAR) modulators may not only enhance early p...

Descripción completa

Detalles Bibliográficos
Autores principales: Lynch, Caitlin, Zhao, Jinghua, Huang, Ruili, Xiao, Jingwei, Li, Linhao, Heyward, Scott, Xia, Menghang, Wang, Hongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438668/
https://www.ncbi.nlm.nih.gov/pubmed/25993555
http://dx.doi.org/10.1038/srep10405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438668/
https://www.ncbi.nlm.nih.gov/pubmed/25993555
http://dx.doi.org/10.1038/srep10405

Ejemplares similares